i-mass guides : Index | Classic Articles | Definitions | History | Movies | Nobel Prizes | Protocols | Resources | Techniques | Troubleshooting | Tutorials

Past Features

WWW ChemTools

  • Ion Formula by Mol. Weight
  • Isotope Pattern Calculator
  • Mass Loss Calculator
  • Periodic e-Table

WWW BioTools

  • EMBL Peptide Search - protein ID from peptide mass and sequence data
  • FindMod - post-translational modifications by peptide mass
  • GlycanMass - oligosaccharide mass from structure
  • GlycoMod - oligosaccharide structures from mass
  • GlycoSuiteDB - search database with oligosaccharide mass
  • Javascript Protein Digest - peptide digest masses
  • Javascipt Fragment Ion Generator for peptides
  • Mascot Search - peptide mass and sequence tools
  • Mowse - protein identification from peptide MS data
  • Protein Prospector - mass spectra interpretation tools
  • PROWL - identification of proteins from MS data

past feature

Mass Spectrometry Skills in Demand for Drug Discovery

John Michnowicz, the Proteomics Program Manager for Agilent Technologies, describes the value of mass spectrometry skills in drug discovery teams in a Nature Drug Discovery article.

Broadly trained scientists with mass spectrometry skills add great value to drug discovery teams according to Michnowicz. During the past decade, the technological improvements in mass spectrometry have had a significant impact on drug discovery and development. Modern liquid chromatography/mass spectrometry (LC/MS) using the various forms of atmospheric-pressure ionization (API) and matrix-assisted laser desorption ionization (MALDI) have made the identification and quantification of complex and liable molecules a routine procedure. Oligonucleotides, peptides, proteins and small-molecule drug candidates can be now be screened using mass spectrometry in a highly automated, high-throughput manner.

But Michnowicz notes that although manufacturers have greatly simplified the operation of mass spectrometers, the average mass-spectrometer laboratory will normally be staffed with several Ph.D.-level scientists who have expertise in mass spectrometry. This has placed a great demand for people with expertise in this technique. The current shortage of MS talent clearly opens up significant opportunities for students entering universities to study advanced degrees.

A new graduate with a solid MS background is 'hot property' in today's employment environment, but this value is considerably enhanced by knowledge of an application area, such as biochemistry or toxicology.

The full article appears in
Nature Drug Discovery.



MS Journals

  • European Mass Spectrom.
  • Intl. J. of Mass Spectrom.
  • J. American Society of MS
  • J. Mass Spectrometry
  • J. MS Society of Japan
  • Mass Spectrometry Reviews
  • Rapid Communications in MS

Science Journals

  • Analyst
  • Analytical Chemistry
  • Nature
  • New Scientist
  • Science
  • Scientific American

Literature Search

  • Beilstein Abstracts
  • ChemWeb
  • Current Contents - ISI
  • PubMed - NCBI
  • PubScience - DOE

World Laboratories


Copyright www.i-mass.com. All rights reserved worldwide.

Related Links

Resource Links